Punchama Pacharn* , Nunthana Siripipattanamongkol, Jittima Veskitkul, Orathai Jirapongsananuruk, Nualanong Visitsunthorn, and Pakit Vichyanond
Division of Allergy and Immunology, Department of Pediatrics, Siriraj Hospital, Mahidol University Faculty of Medicine, Bangkok 10700, Thailand We reported a successful oral immunotherapy (OIT) in 2 children with high wheat sensitivity (4 and 14 years old boys). Oral challenges indicated eliciting doses of 300 mg, and wheat flour of 30 mg. The OIT protocol includes 5 days of build-up phase in the hospital, intervening with 2 to 5 months of home maintenance phase. Patients could tolerate 45 g, and 60 g of wheat flour per day, respectively. We have demonstrated that OIT to a large amount of wheat in extremely sensitized patients could be achieved with a stepwise multi oral/maintenance regimen. Key words: Immunologic desensitization; Wheat allergy
LINK TO: Successful wheat-specific oral immunotherapy in highly sensitive individuals with a novel multirush/maintenance regimen. Asia Pac Allergy. 2014 Jul;4(3):180-3.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116039/pdf/apa-4-180.pdf
