Food Allergy: Our Evolving Understanding of Its Pathogenesis, Prevention, and Treatment. 2015

Food Allergy: Our Evolving Understanding of Its Pathogenesis, Prevention, and Treatment.

Abstract

Food allergy is defined as an IgE-mediated hypersensitivity response to ingested food with allergic symptoms ranging from urticaria to life-threatening anaphylaxis. Food allergy is thought to develop because of (1) failed induction of tolerance upon initial exposure to food antigen or (2) breakdown of established tolerance to food antigen. We review current understanding of the pathogenesis, epidemiology, and natural history of food allergy, including the unconventional IgE-mediated food allergy to mammalian meat known as alpha-gal food allergy. We highlight emerging data on food allergy treatment and prevention, emphasizing the growing appeal of manipulating the gut microenvironment using probiotics and helminth products to blunt systemic allergic responses to food.

KEYWORDS:

Alpha-gal; Food allergy; Helminth; Microbiota; Peanut allergy; Probiotics

 Link To:
Kulis M1, Wright BL2, Jones SM3, Burks AW4.
Diagnosis, management, and investigational therapies for food allergies.
Gastroenterology. 2015 May;148(6):1132-42. doi: 10.1053/j.gastro.2015.01.034. Epub 2015 Jan 26.
http://www.ncbi.nlm.nih.gov/pubmed/27041704
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4793977/

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