Anti-IgE-assisted desensitization to egg and cow’s milk in patients refractory to conventional oral immunotherapy. 2016

Anti-IgE-assisted desensitization to egg and cow’s milk in patients refractory to conventional oral immunotherapy.

Abstract

Oral immunotherapy (OIT) is a significant focus of treatment for egg and cow’s milk food allergy, inducing desensitization in the majority of individuals with these sensitivities (1,2). A major drawback of OIT is the frequency of adverse effects and although most are mild and self-limited the use of parenteral epinephrine is not infrequent. As many as 20-30% of food allergic patients are refractory to desensitization, particularly patients with higher initial food-specific IgE levels (3). To address some of the safety issues associated with OIT, anti-IgE monoclonal antibody (omalizumab) was proposed as an adjunct to facilitate OIT by reducing OIT-induced allergic reactions. This article is protected by copyright. All rights reserved.

This article is protected by copyright. All rights reserved.

KEYWORDS:

Cow’s milk allergy; Hen’s egg allergy; Immune tolerance; Monoclonal anti-IgE; Specific oral tolerance induction (SOTI)

Link To: Anti-IgE-assisted desensitization to egg and cow’s milk in patients refractory to conventional oral immunotherapy., Pediatr Allergy Immunol. 2016 Mar 22.

http://www.ncbi.nlm.nih.gov/pubmed/27003835

 

 

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